Goldberger J H, Cha C J, Hazard W L, Randall H T, Clowes G H
Surgery. 1976 Oct;80(4):493-7.
Forty-five patients who underwent a 14 by 4 inch jejunoileal bypass for morbid obesity were studied before the operation and at periodic intervals after operation to determine the complications and changes in body composition resulting from this procedure. Body composition studies were determined using 3H2O and 42K. Rapid weight loss occurred in the first 3 months, with a mean loss of 30 percent of excess weight. This weight loss was accompanied by a decrease in exchangeable potassium (Ke) and total body water (TBW) during this interval by 14 and 10 percent, respectively. Although most patients continued to lose excess weight Ke and TBW stabilized at the end of the first year and returned to preoperative values in six patients at the end of 24 months. Analysis of the ratios of body cell mass and total body water to weight shows an improvement of body composition 12 months after operation. Body composition studies permit a quantitative assessment of the nutritional status in patients undergoing jejunoileal bypass. In spite of significant complications (23 percent), surgery for morbid obesity appears to satisfy the objective of allowing desirable loss of fat with relative sparing of muscle and other supporting tissues.
对45例因病态肥胖接受14×4英寸空肠回肠旁路手术的患者在术前及术后定期进行研究，以确定该手术引起的并发症及身体成分变化。使用3H2O和42K测定身体成分。最初3个月体重迅速减轻，平均减轻超重部分的30%。在此期间，可交换钾（Ke）和总体水（TBW）分别减少了14%和10%。尽管大多数患者继续减轻超重部分，但Ke和TBW在第一年末趋于稳定，24个月末有6例患者恢复到术前值。术后12个月身体细胞质量与总体水与体重之比的分析显示身体成分有所改善。身体成分研究有助于对接受空肠回肠旁路手术患者的营养状况进行定量评估。尽管有显著并发症（23%），但病态肥胖手术似乎达到了理想的减脂目标，同时相对保留了肌肉和其他支持组织。
