Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.
作者信息
Nikaido H, Thanassi D G
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
出版信息
Antimicrob Agents Chemother. 1993 Jul;37(7):1393-9. doi: 10.1128/AAC.37.7.1393.
Abstract
摘要
相似文献
1
Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.具有多个质子化位点的亲脂性药物进入细菌细胞的机制：以四环素和氟喹诺酮类药物为例
Antimicrob Agents Chemother. 1993 Jul;37(7):1393-9. doi: 10.1128/AAC.37.7.1393.
2
[Mechanism of action and resistance to fluoroquinolones].[氟喹诺酮类药物的作用机制与耐药性]
Enferm Infecc Microbiol Clin. 1996 Feb;14(2):111-7.
3
Bacterial cell penetration by beta3-oligohomoarginines: indications for passive transfer through the lipid bilayer.β3-寡聚高精氨酸对细菌细胞的穿透作用：通过脂质双层被动转运的证据
Chembiochem. 2005 Jun;6(6):982-5. doi: 10.1002/cbic.200400394.
4
[Penetration and intracellular activity of fluoroquinolones].
Enferm Infecc Microbiol Clin. 1998 Mar;16(3):138-43.
5
Antimicrobial agents for the dermatologist. II. Macrolides, fluoroquinolones, rifamycins, tetracyclines, trimethoprim-sulfamethoxazole, and clindamycin.皮肤科医生的抗菌药物。II. 大环内酯类、氟喹诺酮类、利福霉素类、四环素类、甲氧苄啶-磺胺甲恶唑及克林霉素。
J Am Acad Dermatol. 1997 Sep;37(3 Pt 1):365-81; quiz 382-4. doi: 10.1016/s0190-9622(97)70135-x.
6
7
Quantitative comparison of cytocidal effects of tetracyclines and fluoroquinolones on human periodontal ligament fibroblasts.
J Periodontal Res. 1999 Aug;34(6):290-5. doi: 10.1111/j.1600-0765.1999.tb02256.x.
8
[The place of fluoroquinolones in the treatment of bacterial infections].[氟喹诺酮类药物在细菌感染治疗中的地位]
Antibiot Khimioter. 1999;44(12):27-30.
9
NM441: penetration into gynaecological tissues and in vitro activity against clinical isolates from obstetric and gynaecological patients.
Drugs. 1995;49 Suppl 2:326-30. doi: 10.2165/00003495-199500492-00087.
10
Antibiotic susceptibilities of Parachlamydia acanthamoeba in amoebae.棘阿米巴中嗜肺军团菌的抗生素敏感性
Antimicrob Agents Chemother. 2002 Sep;46(9):3065-7. doi: 10.1128/AAC.46.9.3065-3067.2002.
引用本文的文献
1
Algal Metabolites as Novel Therapeutics Against Methicillin-Resistant (MRSA): A Review.藻类代谢产物作为抗耐甲氧西林金黄色葡萄球菌（MRSA）的新型疗法：综述
Pharmaceutics. 2025 Jul 30;17(8):989. doi: 10.3390/pharmaceutics17080989.
2
Hfq influences ciprofloxacin accumulation in Escherichia coli independently of ompC and ompF post-transcriptional regulation.Hfq独立于ompC和ompF的转录后调控影响环丙沙星在大肠杆菌中的积累。
J Appl Genet. 2025 May;66(2):449-457. doi: 10.1007/s13353-025-00945-9. Epub 2025 Feb 8.
3
Biological control of bacterial leaf blight (BLB) in rice-A sustainable approach.水稻白叶枯病的生物防治——一种可持续的方法。
Heliyon. 2025 Jan 8;11(2):e41769. doi: 10.1016/j.heliyon.2025.e41769. eCollection 2025 Jan 30.
4
A genomics approach provides insight into the mode of action of biocides.
Nat Microbiol. 2023 Nov;8(11):1948-1949. doi: 10.1038/s41564-023-01475-y.
5
Systematic analyses identify modes of action of ten clinically relevant biocides and antibiotic antagonism in Acinetobacter baumannii.系统分析确定了十种临床相关杀生物剂和抗生素拮抗作用在鲍曼不动杆菌中的作用模式。
Nat Microbiol. 2023 Nov;8(11):1995-2005. doi: 10.1038/s41564-023-01474-z. Epub 2023 Oct 9.
6
Investigation of d-Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents.基于d-氨基酸的表面活性剂以及含金和二氧化硅纳米颗粒的纳米复合材料作为抗多重耐药菌剂的研究。
ACS Omega. 2022 Dec 8;7(50):46146-46155. doi: 10.1021/acsomega.2c04220. eCollection 2022 Dec 20.
7
New understanding of multidrug efflux and permeation in antibiotic resistance, persistence, and heteroresistance.对抗生素耐药性、持久性和异质性耐药性中多药外排和渗透的新认识。
Ann N Y Acad Sci. 2023 Jan;1519(1):46-62. doi: 10.1111/nyas.14921. Epub 2022 Nov 7.
8
Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes.沙门氏菌感染被两种小分子扰乱，这两种小分子在吞噬体中积累并使细菌内膜产生差异损伤。
mBio. 2022 Oct 26;13(5):e0179022. doi: 10.1128/mbio.01790-22. Epub 2022 Sep 22.
9
The Putative Major Facilitator Superfamily (MFS) Protein Named Rv1877 in Mycobacterium tuberculosis Behaves as a Multidrug Efflux Pump.结核分枝杆菌中假定的主要易化超家族（MFS）蛋白 Rv1877 表现为一种多药外排泵。
Curr Microbiol. 2022 Sep 20;79(11):324. doi: 10.1007/s00284-022-03021-1.
10
Analysis of Orthogonal Efflux and Permeation Properties of Compounds Leads to the Discovery of New Efflux Pump Inhibitors.化合物的正交外排和渗透特性分析导致新的外排泵抑制剂的发现。
ACS Infect Dis. 2022 Oct 14;8(10):2149-2160. doi: 10.1021/acsinfecdis.2c00263. Epub 2022 Sep 7.
本文引用的文献
1
DETERMINATION OF A PROTONATION SCHEME OF TETRACYCLINE USING NUCLEAR MAGNETIC RESONANCE.
Anal Chem. 1965 Jun;37:872-5. doi: 10.1021/ac60226a022.
2
Avidity of the tetracyclines for the cations of metals.四环素对金属阳离子的亲合力。
Nature. 1956 Mar 3;177(4505):433-4. doi: 10.1038/177433a0.
3
Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.大肠杆菌中由四种基因不同的四环素抗性决定簇编码的四环素主动外排
Proc Natl Acad Sci U S A. 1980 Jul;77(7):3974-7. doi: 10.1073/pnas.77.7.3974.
4
Transport of the lipophilic analog minocycline differs from that of tetracycline in susceptible and resistant Escherichia coli strains.在敏感和耐药的大肠杆菌菌株中，亲脂性类似物米诺环素的转运与四环素不同。
Antimicrob Agents Chemother. 1982 Nov;22(5):791-9. doi: 10.1128/AAC.22.5.791.
5
Tetracycline diffusion through phospholipid bilayers and binding to phospholipids.四环素通过磷脂双分子层的扩散及其与磷脂的结合。
Antimicrob Agents Chemother. 1984 Aug;26(2):263-5. doi: 10.1128/AAC.26.2.263.
6
Tetracyclines of various hydrophobicities as a probe for permeability of Escherichia coli outer membranes.不同疏水性四环素作为大肠杆菌外膜通透性的探针
Antimicrob Agents Chemother. 1984 May;25(5):539-44. doi: 10.1128/AAC.25.5.539.
7
Energetics of tetracycline transport into Escherichia coli.四环素转运至大肠杆菌的能量学
Antimicrob Agents Chemother. 1984 Apr;25(4):446-9. doi: 10.1128/AAC.25.4.446.
8
Stoichiometry of the H+-ATPase of growing and resting, aerobic Escherichia coli.生长和静止的好氧大肠杆菌H⁺-ATP酶的化学计量学
Biochemistry. 1982 Oct 26;21(22):5534-8. doi: 10.1021/bi00265a024.
9
Antibiotic uptake by bacteria as measured by partition in polymer aqueous phase systems.通过聚合物水相体系中的分配来测定细菌对抗生素的摄取。
Anal Biochem. 1984 Aug 15;141(1):94-100. doi: 10.1016/0003-2697(84)90430-5.
10
Permeability of lipid bilayer membranes to organic solutes.脂质双分子层膜对有机溶质的通透性。
J Gen Physiol. 1968 Sep;52(3):495-508. doi: 10.1085/jgp.52.3.495.
Zotero 插件