HLA区域存在重组的家族中主要组织相容性复合体基因座的连锁关系。

Linkage relationships of the loci of the major histocompatibility complex in families with a recombination in the HLA region.

作者信息

Bijnen A B, Schreuder I, Meera Khan P, Allen F H, Giles C M, Los W R, Volkers W S, van Rood J J

出版信息

J Immunogenet. 1976 Jun;3(3):171-83. doi: 10.1111/j.1744-313x.1976.tb00570.x.

DOI:10.1111/j.1744-313x.1976.tb00570.x

Abstract

A number of families with an established recombination in the major histocompatibility complex has been investigated for markers known to be coded by genes of this linkage group. The results provide further data on the relative position of the loci for HLA-A, HLA-B, HLA-C, HLA-D, Bf, Chido, Rodgers and PGM3 on chromosome 6. A positive lodscore for linkage between HLA and blood group P was found; lodscores between HLA and nineteen other markers were negative.

摘要

对一些主要组织相容性复合体中已确定存在重组的家族进行了研究，以寻找已知由该连锁群基因编码的标记。这些结果为6号染色体上HLA - A、HLA - B、HLA - C、HLA - D、Bf、Chido、Rodgers和PGM3基因座的相对位置提供了更多数据。发现HLA与血型P之间连锁的对数优势比为正值；HLA与其他19个标记之间的对数优势比为负值。