Bünemann H, Gauwerky F, Langheim F, Schirrmeister D
Strahlentherapie. 1976 Sep;152(3):203-34.
The main problems of radiotherapy planning are discussed with respect to use of computers now being available for a greater number of centers. One of the most essential premises is apart from clear ideas on a modern target volume concept - a sufficiently high speed in producing realistic summarized isodose contours for any radiation therapy arrangement in any individual patient's cross section outline. This problem being solved, those individual summarized isodose figures have to be critically evaluated and therefore the importance of applicable meaningful optimization criteria come into account. The properties of such criteria, which must be quantifiable, generally applicable and really relevant for judgement on quality of a plan, had to be accepted, before automatic optimization procedures could be developed; principles involved are presented. By means of a short series of examples, namely 60Co fixed field combinations with and without use of wedges, combinations of arc therapy for a number of clinical tasks. It has been pointed out, that most experienced estimate by the eye would have been by far insufficient when compared to the automized computer optimization when using such simple criteria as 1. homogeneity of absorbed dose within target volume, 2. numerically limited absorbed dose within areas of risk, 3. as low as possible radiation effects to all "outside areas". It seems to be a real danger, that so called isodose libraries, how high their merits might be estimated, may change into an "isodose bcemetery", unless we'll be successful for each individual clinical case by use of computers, which are now prepared to supply the best possible variant of the standard plan or the primary radiotherapy idea. Regular use of computers in such a way will furthermore give an incomparable documentation material.
结合目前越来越多中心可使用的计算机,讨论了放射治疗计划的主要问题。最重要的前提之一是,除了对现代靶区概念有清晰的认识外,对于任何个体患者横断面轮廓中的任何放射治疗方案,都要能足够快速地生成逼真的汇总等剂量线轮廓。解决了这个问题后,还必须对这些个体汇总等剂量数值进行严格评估,因此要考虑适用的有意义的优化标准的重要性。在开发自动优化程序之前,必须接受此类标准的属性,这些属性必须是可量化的、普遍适用的且与计划质量判断真正相关的;文中介绍了相关原则。通过一系列简短的示例,即60钴固定野组合(有无楔形板)、多种临床任务的弧形治疗组合,指出在使用诸如1. 靶区内吸收剂量的均匀性、2. 危险区内数值受限的吸收剂量、3. 对所有“外部区域”尽可能低的辐射效应等简单标准时,与自动化计算机优化相比,最有经验的肉眼估计远远不够。似乎存在一个真正的危险,即所谓的等剂量库,无论其优点被估计得有多高,都可能变成一个“等剂量墓地”,除非我们能通过使用计算机成功地为每个临床病例提供标准计划或主要放射治疗方案的最佳可能变体。以这种方式定期使用计算机还将提供无与伦比的文档资料。