Premoli-De-Percoco G, Ramírez J L, Galindo I
Centro de Investigaciones Odontológicas, Facultad de Odontología, Universidad de los Andes, Mérida, Venezuela.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Jul;86(1):77-81. doi: 10.1016/s1079-2104(98)90153-6.
Epidemiologic and clinical evidence suggests a possible relationship between the human papillomavirus types found in oral squamous cell carcinoma and cervicovaginal cancer. To try to address this question, we analyzed by in situ hybridization 50 paraffin-embedded biopsies of oral squamous cell carcinomas and their corresponding Papanicolaou smears using nonradioactive DNA probes for human papillomavirus type 6/11 and 16/18. This analysis revealed that 70% (35 of 50) of oral squamous cell carcinomas and 56% (28 of 50) of Papanicolaou smears were positive for one or both of these human papillomavirus DNA probes. In 23 of the 28 patients who were positive for human papillomavirus sequences in the cervicovaginal tract, we found the same human papillomavirus type in the oral cavity. Five of the positive in situ hybridization Papanicolaou smears were associated with negative in situ hybridization oral squamous cell carcinomas. Our data suggest that after a primary infection by human papillomavirus, other mucosal sites may eventually become infected. Local environmental factors may contribute to the pathogenesis of lesions such as oral squamous cell carcinoma.
流行病学和临床证据表明，口腔鳞状细胞癌中发现的人乳头瘤病毒类型与宫颈阴道癌之间可能存在关联。为了试图解决这个问题，我们使用针对人乳头瘤病毒6/11型和16/18型的非放射性DNA探针，通过原位杂交分析了50例口腔鳞状细胞癌石蜡包埋活检标本及其相应的巴氏涂片。该分析显示，70%（50例中的35例）的口腔鳞状细胞癌和56%（50例中的28例）的巴氏涂片对这两种人乳头瘤病毒DNA探针中的一种或两种呈阳性。在宫颈阴道部位人乳头瘤病毒序列呈阳性的28例患者中的23例中，我们在口腔中发现了相同的人乳头瘤病毒类型。5例原位杂交阳性的巴氏涂片与原位杂交阴性的口腔鳞状细胞癌相关。我们的数据表明，人乳头瘤病毒初次感染后，其他黏膜部位最终可能会被感染。局部环境因素可能有助于口腔鳞状细胞癌等病变的发病机制。
