Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
Planta Med. 2010 May;76(7):705-7. doi: 10.1055/s-0029-1240681. Epub 2009 Dec 3.
A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ENT-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A ( 1), I ( 2), and R ( 3), as well as of two pseudoguaianolids, damsin ( 4) and confertin ( 5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.
对两种秘鲁药用植物大羽苔（Plagiochila disticha）和豚草（Ambrosia peruviana）的乙醇提取物和馏分进行了药理学筛选，从中分离并鉴定了三种 ENT-2,3-裂环阿瑞木烷型倍半萜，分别命名为大羽苔烯 A（1）、I（2）和 R（3），以及两种伪愈创木烷类化合物，dam-sin（4）和 confertin（5），它们对一组人肿瘤细胞系表现出显著的细胞毒性活性。化合物 1、4 和 5 还被测试了它们的体外抗利什曼原虫、杀锥虫和抗结核活性，分别针对利什曼原虫无鞭毛体和克氏锥虫锥虫体，以及耐多药和敏感株的结核分枝杆菌。
