Moura J R, Prado M A, Gomez M V, Kalapothakis E, Diniz C R, Cordeiro M N, Romano-Silva M A
Departamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte-MG, Brasil.
Toxicon. 1998 Aug;36(8):1189-92. doi: 10.1016/s0041-0101(98)00094-4.
Venoms from spiders are an important source of toxins that can help on the dissection of mechanisms involved in neurotransmission. Among them is the venom of the spider Phoneutria nigriventer that contains several toxic fractions with different targets in mammals and/or insects. We here report that one of these fractions (PhTx2) is able to evoke acetylcholine release from rat cortical synaptosomes and that this effect is dependent on extracellular calcium and is inhibited by the sodium channel blocker tetrodotoxin.
蜘蛛毒液是毒素的重要来源，有助于剖析神经传递所涉及的机制。其中包括黑腹捕鸟蛛的毒液，它含有几种对哺乳动物和/或昆虫具有不同靶点的毒性成分。我们在此报告，这些成分之一（PhTx2）能够诱发大鼠皮层突触体释放乙酰胆碱，且这种效应依赖于细胞外钙，并受到钠通道阻滞剂河豚毒素的抑制。
