Deakin J F
Neuroscience and Psychiatry Unit, University of Manchester, UK.
Int Clin Psychopharmacol. 1998 Apr;13 Suppl 4:S1-5. doi: 10.1097/00004850-199804004-00001.
Anxiety and depressive disorders occur across a broad spectrum, and each different disorder may involve distinct genetic and neurobiologica/neurochemical mechanisms. Many classes of drug are available for the treatment of these disorders and, as might be expected, these drugs exhibit a variety of biochemical actions. Paradoxically, the single-action selective serotonin reuptake inhibitors are effective in a range of these disorders. However, the paradox may be resolved by an understanding of the distinct ways in which serotonin modifies the physiological coping mechanisms that become dysfunctional in these disorders.
焦虑症和抑郁症呈现出广泛的谱系，每一种不同的病症可能涉及不同的遗传和神经生物学/神经化学机制。有许多类药物可用于治疗这些病症，不出所料，这些药物表现出各种各样的生化作用。矛盾的是，单作用选择性5-羟色胺再摄取抑制剂对一系列此类病症有效。然而，通过了解5-羟色胺改变在这些病症中功能失调的生理应对机制的不同方式，或许可以解决这一矛盾。
