Ormerod L P, Horsfield N, Alani F S
Chest Clinic, Blackburn Royal Infirmary, U.K.
Respir Med. 1998 Mar;92(3):599-600. doi: 10.1016/s0954-6111(98)90317-1.
Isolated endobronchial secondaries are reported usually as single cases or in series from either specialist surgical or cancer units. The latter two are selected populations and are not a good guide to the true frequency of occurrence of such isolated endobronchial secondaries. The incidence of such endobronchial secondaries in a 15 yr prospective series is reported. Results of all fibre-optic bronchoscopies carried out in the Blackburn, Hyndburn and Ribble Valley districts from 1981 to 1995 together with histology were recorded prospectively throughout the period. These had been audited yearly throughout, the data were collated, and the individual records of cases of endobronchial secondaries examined. A total of 3353 bronchoscopies were carried out in the years 1981-1995 inclusive. Of these, 1391 had visible endobronchial abnormalities, from which 1059 had positive endobronchial histology. Sixteen of the 1059 (1.5%) were with endobronchial secondaries. Over the same period eight bronchial carcinoids (none biopsied, but later surgically resected) were encountered. Isolated endobronchial secondaries made up a higher proportion of endobronchial histology than expected at 1.5% and were twice as frequently found as bronchial carcinoids. The possibility of endobronchial secondaries should always be considered in those with a history of previous carcinomas at other sites.
孤立性支气管内转移瘤通常作为单个病例或由专科外科或癌症科室以系列病例形式报道。后两者是特定人群，不能很好地反映此类孤立性支气管内转移瘤的真实发生频率。本文报道了一个为期15年的前瞻性系列研究中此类支气管内转移瘤的发生率。1981年至1995年期间在布莱克本、欣德伯恩和里布尔谷地区进行的所有纤维支气管镜检查结果及组织学情况在此期间均进行了前瞻性记录。这些检查每年都进行审核，数据进行了整理，并对支气管内转移瘤病例的个体记录进行了检查。1981年至1995年（含）期间共进行了3353次支气管镜检查。其中，1391次检查发现支气管内有可见异常，其中1059次支气管内组织学检查呈阳性。1059例中有16例（1.5%）为支气管内转移瘤。在同一时期，发现了8例支气管类癌（均未活检，但后来进行了手术切除）。孤立性支气管内转移瘤在支气管内组织学检查中所占比例高于预期的1.5%，其发现频率是支气管类癌的两倍。对于有其他部位既往癌症病史的患者，应始终考虑支气管内转移瘤的可能性。
