急性心肌梗死患者循环单核白细胞中β-内啡肽水平降低。

Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction.

作者信息

Buratti T, Schratzberger P, Dunzendorfer S, Manfreda S E, Pechlaner C, Joannidis M, Sacerdote P, Panerai A E, Wiedermann C J

机构信息

Intensive Care Unit, Department of Medicine, University of Innsbruck, Austria.

出版信息

Cardiology. 1998 Jul;90(1):43-7. doi: 10.1159/000006815.

DOI:10.1159/000006815

PMID:9693170

Abstract

Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive beta-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of beta-endorphin in mononuclear leukocytes of 30.2 +/- 6.9 pg/10(6) cells on admission were in the normal range of 20-40 pg/10(6) cells and decreased significantly to 6.9 +/- 1.9 pg/10(6) cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated beta-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.

摘要

淋巴细胞可被激活以产生和释放阿片肽。我们研究了11例急性心肌梗死患者外周血单核细胞中免疫反应性β-内啡肽的水平。入院时单核白细胞中β-内啡肽的浓度为30.2±6.9 pg/10(6) 个细胞，处于20 - 40 pg/10(6) 个细胞的正常范围内，48小时后显著降至6.9±1.9 pg/10(6) 个细胞（p < 0.05）。急性心肌梗死中单核白细胞相关β-内啡肽水平降低可能是由于应激和急性期反应物刺激后内源性阿片类物质的释放，并在炎症和疼痛中起作用。