风湿性疾病患者单核白细胞中免疫反应性β-内啡肽减少。
Decreased immunoreactive beta-endorphin in mononuclear leucocytes from patients with rheumatic diseases.
作者信息
Wiedermann C J, Sacerdote P, Mur E, Kinigadner U, Wicker T, Panerai A E, Braunsteiner H
机构信息
Department of Internal Medicine, School of Medicine, University of Innsbruck, Austria.
出版信息
Clin Exp Immunol. 1992 Feb;87(2):178-82. doi: 10.1111/j.1365-2249.1992.tb02971.x.
The neuroendocrine polypeptide hormone beta-endorphin (beta-END), which is released from various tissues including the anterior pituitary gland and cells of the immune system, has recently been implicated as having an immunoregulatory role. We used a radioimmunoassay to measure beta-END levels in circulating mononuclear leucocytes from normal subjects and patients with various rheumatic diseases. Levels of beta-END in leucocytes from patients were lower than in leucocytes from healthy subjects (P less than 0.001). Whereas levels of beta-END in leucocytes from patients with the various rheumatic disorders were not significantly different, an inverse correlation was found between beta-END levels in leucocytes and expression of rheumatoid factor (P less than 0.025) and erythrocyte sedimentation rate (P less than 0.025). This study demonstrates decreased content of beta-END in cells of the immune system related to parameters of inflammatory activity in rheumatic diseases.
神经内分泌多肽激素β-内啡肽（β-END）可从包括垂体前叶和免疫系统细胞在内的多种组织中释放出来，最近有研究表明它具有免疫调节作用。我们采用放射免疫分析法测定了正常受试者和各类风湿性疾病患者循环单核白细胞中的β-END水平。患者白细胞中的β-END水平低于健康受试者白细胞中的水平（P<0.001）。虽然各类风湿性疾病患者白细胞中的β-END水平无显著差异，但发现白细胞中β-END水平与类风湿因子表达（P<0.025）和红细胞沉降率（P<0.025）呈负相关。本研究表明，与风湿性疾病炎症活动参数相关的免疫系统细胞中β-END含量降低。
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