Valenta R, Almo S, Ball T, Dolecek C, Steinberger P, Laffer S, Eibensteiner P, Flicker S, Vrtala S, Spitzauer S, Valent P, Denepoux S, Kraft D, Banchereau J, Lebecque S
Department of General and Experimental Pathology, University of Vienna, Austria.
Int Arch Allergy Immunol. 1998 Jul;116(3):167-76. doi: 10.1159/000023942.
The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leads in sensitized individuals through effector cell activation to the immediate induction of a cascade of inflammatory reactions, the hallmark of type I allergy. Recently, the molecular and structural characterization of allergens, specific IgE antibodies and their epitopes has made rapid progress. Here we discuss active and passive strategies for therapy of type I allergy, which are based on interfering with the IgE-allergen interaction.
免疫球蛋白E与原本无害的抗原（过敏原）相互作用，会使致敏个体通过效应细胞激活，立刻引发一系列炎症反应，这是I型过敏的标志。最近，过敏原、特异性IgE抗体及其表位的分子和结构特征研究取得了迅速进展。在此，我们讨论基于干扰IgE-过敏原相互作用的I型过敏的主动和被动治疗策略。
