Ishiko S, Yoshida A, Mori F, Abiko T, Kitaya N, Konno S, Kato Y
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Ophthalmologica. 1998;212(5):301-5. doi: 10.1159/000027312.
To study the early ocular abnormalities in young diabetic patients, corneal and lens autofluorescence was measured by fluorophotometry in 30 eyes of 30 insulin-dependent diabetic patients without retinopathy. The lens [f(l)] and the corneal [f(c)] autofluorescence values in diabetic patients were significantly higher than in controls. In diabetic patients, f(l) was significantly correlated with the duration of diabetes, the f(c) was significantly correlated with the duration of diabetes and the indices of metabolic control, i.e. HbA1c and fructosamine. Our study demonstrated that young diabetic patients clearly had corneal and lens abnormalities before the appearance of overt diabetic retinopathy. The f(c) value might be a good indicator of metabolic control in diabetic patients.
为研究年轻糖尿病患者的早期眼部异常情况，采用荧光光度法对30例无视网膜病变的胰岛素依赖型糖尿病患者的30只眼进行了角膜和晶状体自体荧光测量。糖尿病患者的晶状体[f(l)]和角膜[f(c)]自体荧光值显著高于对照组。在糖尿病患者中，f(l)与糖尿病病程显著相关，f(c)与糖尿病病程以及代谢控制指标（即糖化血红蛋白和果糖胺）显著相关。我们的研究表明，年轻糖尿病患者在明显的糖尿病视网膜病变出现之前就明显存在角膜和晶状体异常。f(c)值可能是糖尿病患者代谢控制的一个良好指标。
