Klinger G, Eick S, Klinger G, Pfister W, Gräser T, Moore C, Oettel M
Department of Conservative Dentistry, Medical Faculty, Friedrich-Schiller-University, Jena, Germany.
Contraception. 1998 Jun;57(6):381-4. doi: 10.1016/s0010-7824(98)00044-4.
To determine a possible influence of two different hormonal contraceptives on bacterial microflora of gingival sulcus, subgingival plaque samples of 29 healthy women aged between 20 and 32 years were investigated bacteriologically before subjects took a contraceptive and 10 and 20 days after subjects started the medication. In 14 women, and oral contraceptive containing 0.02 mg ethinyl estradiol and 0.15 mg desogestrel (preparation A) was used, and 15 women took a contraceptive containing 0.03 mg ethinyl estradiol and 2.00 mg dienogest (preparation B) daily over 21 days. There were no changes in clinical parameters of the teeth investigated during 3 weeks of the study. The periodontopathogenic bacteria Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans were never detected throughout the study. On the other hand, the periodontopathogenic species Prevotella intermedia was found in plaque samples of 22 women. The content of this microorganism showed only a little change between the pretreatment period and plaque sampling after 10 days of contraceptive treatment, but a striking increase occurred after 20 days of contraceptive treatment, especially in the preparation A group. In this respect, there was a significant difference between preparations A and B.
为了确定两种不同激素避孕药对龈沟细菌微生物群的可能影响，对29名年龄在20至32岁之间的健康女性的龈下菌斑样本进行了细菌学调查，调查时间为受试者服用避孕药前以及开始用药后10天和20天。14名女性使用了含有0.02mg炔雌醇和0.15mg去氧孕烯的口服避孕药（制剂A），15名女性在21天内每天服用含有0.03mg炔雌醇和2.00mg地诺孕素的避孕药（制剂B）。在研究的3周内，所调查牙齿的临床参数没有变化。在整个研究过程中从未检测到牙周病原菌牙龈卟啉单胞菌和伴放线放线杆菌。另一方面，在22名女性的菌斑样本中发现了牙周病原菌中间普氏菌。这种微生物的含量在预处理期和避孕药治疗10天后的菌斑采样之间仅略有变化，但在避孕药治疗20天后显著增加，尤其是在制剂A组。在这方面，制剂A和制剂B之间存在显著差异。
