Laiho K, Tiitinen S, Teppo A M, Kauppi M, Kaarela K
Rheumatism Foundation Hospital, Heinola, Finland.
Clin Rheumatol. 1998;17(3):234-5. doi: 10.1007/BF01451054.
We studied whether the low serum C-reactive protein (S-CRP) level in patients with inflammatory arthritis and proteinuria was due to the loss of CRP into urine. In 19 patients with secondary amyloidosis (14 with rheumatoid arthritis and five with juvenile chronic arthritis), S-CRP was measured with both immunoturbidimetric and radioimmunoassays. The concentration of urinary CRP was measured with a double-antibody radioimmunoassay. One patient with the most extensive proteinuria (12 g/24 h) excreted CRP at 14 mg/24 h, while in 18 of 19 patients only negligible, if any, amounts of CRP were found in 24-h urine samples. Proteinuria of < 8 g/24 h did not reduce the S-CRP level. Proteinuria exceeding this level may result in increased excretion of CRP into urine and consequently may result in a reduced S-CRP level.
我们研究了炎症性关节炎和蛋白尿患者血清C反应蛋白（S-CRP）水平较低是否是由于CRP流失到尿液中所致。对19例继发性淀粉样变性患者（14例类风湿性关节炎患者和5例青少年慢性关节炎患者），采用免疫比浊法和放射免疫法检测S-CRP。用双抗体放射免疫法检测尿CRP浓度。1例蛋白尿最严重（12 g/24 h）的患者24小时排出CRP 14 mg，而19例患者中有18例在24小时尿液样本中仅发现微量（若有的话）CRP。24小时蛋白尿<8 g不会降低S-CRP水平。超过此水平的蛋白尿可能导致CRP排泄到尿液中增加，从而可能导致S-CRP水平降低。
