Sutcliffe A G, Jones R B, Woodruff G
Department of Pediatrics, Moorfields Eye Hospital, London, UK.
Ophthalmic Genet. 1998 Jun;19(2):59-62. doi: 10.1076/opge.19.2.59.2321.
Four children are presented and their eye malformations described. One girl had bilateral anophthalmos, a boy and a girl had bilateral severe microphthalmos, and a boy had a unilateral optic disc coloboma. The mothers of all for children were treated with carbamazepine during pregnancy. The teratogenic effect of carbamazepine and its likely role in the genesis of the eye malformations is discussed.
本文报告了4例儿童眼畸形病例，并对其进行了描述。1名女孩患有双侧无眼球症，1名男孩和1名女孩患有双侧严重小眼球症，另1名男孩患有单侧视盘缺损。所有4名儿童的母亲在孕期均服用了卡马西平。本文讨论了卡马西平的致畸作用及其在眼畸形发生中的可能作用。
