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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Baptista T, Araujo H, Rada P, Hernández L

Department of Physiology, Medical School, Universidad de los Andes, Mérida, Venezuela.

Prog Neuropsychopharmacol Biol Psychiatry. 1998 Apr;22(3):445-54. doi: 10.1016/s0278-5846(98)00016-5.

A metastatic neuroblastoma was detected immediately after birth in a boy born to a 26 year old woman with bipolar disorder, who received carbamazepine (400 mg/day) all through her pregnancy. The primary tumor was probably located in the adrenal gland of the right side, and multiple metastatic lesions were detected in the skin. 2. In this report the authors review the literature about the side effects teratogenic and carcinogenic effects of carbamazepine, the epidemiology and evolution of the neuroblastoma, and the current scientific opinion about the pharmacological treatment of the pregnant with mood disorders. 3. A causal relationship between the use of carbamazepine and the neuroblastoma development in the present case can not be established; however, as the carcinogenic and teratogenic effects of the drug have been basically assessed in epileptic women, our aim is to alert the medical community in order to conduct further research in psychiatric patients.

一名患有双相情感障碍的26岁女性所生男孩在出生后立即被检测出患有转移性神经母细胞瘤，该女性在整个孕期都服用卡马西平（400毫克/天）。原发性肿瘤可能位于右侧肾上腺，皮肤中检测到多处转移病灶。2. 在本报告中，作者回顾了关于卡马西平的致畸和致癌副作用、神经母细胞瘤的流行病学和演变，以及目前关于患有情绪障碍的孕妇药物治疗的科学观点的文献。3. 本病例中使用卡马西平和神经母细胞瘤发生之间的因果关系无法确定；然而，由于该药物的致癌和致畸作用已在癫痫女性中基本得到评估，我们的目的是提醒医学界以便在精神科患者中开展进一步研究。

Baptista T, Araujo H, Rada P, Hernández L

Department of Physiology, Medical School, Universidad de los Andes, Mérida, Venezuela.

Prog Neuropsychopharmacol Biol Psychiatry. 1998 Apr;22(3):445-54. doi: 10.1016/s0278-5846(98)00016-5.

A metastatic neuroblastoma was detected immediately after birth in a boy born to a 26 year old woman with bipolar disorder, who received carbamazepine (400 mg/day) all through her pregnancy. The primary tumor was probably located in the adrenal gland of the right side, and multiple metastatic lesions were detected in the skin. 2. In this report the authors review the literature about the side effects teratogenic and carcinogenic effects of carbamazepine, the epidemiology and evolution of the neuroblastoma, and the current scientific opinion about the pharmacological treatment of the pregnant with mood disorders. 3. A causal relationship between the use of carbamazepine and the neuroblastoma development in the present case can not be established; however, as the carcinogenic and teratogenic effects of the drug have been basically assessed in epileptic women, our aim is to alert the medical community in order to conduct further research in psychiatric patients.

一名患有双相情感障碍的26岁女性所生男孩在出生后立即被检测出患有转移性神经母细胞瘤，该女性在整个孕期都服用卡马西平（400毫克/天）。原发性肿瘤可能位于右侧肾上腺，皮肤中检测到多处转移病灶。2. 在本报告中，作者回顾了关于卡马西平的致畸和致癌副作用、神经母细胞瘤的流行病学和演变，以及目前关于患有情绪障碍的孕妇药物治疗的科学观点的文献。3. 本病例中使用卡马西平和神经母细胞瘤发生之间的因果关系无法确定；然而，由于该药物的致癌和致畸作用已在癫痫女性中基本得到评估，我们的目的是提醒医学界以便在精神科患者中开展进一步研究。