Bouchard C, Staller P, Eilers M
Institute for Molecular Biology and Tumour Research, University of Marburg, Germany.
Trends Cell Biol. 1998 May;8(5):202-6. doi: 10.1016/s0962-8924(98)01251-3.
Myc proteins are key regulators of mammalian cell proliferation. They are transcription factors that activate genes as part of a heterodimeric complex with the protein Max. This review summarizes recent progress in understanding how Myc stimulates cell proliferation and how this might contribute to cellular transformation and tumorigenesis.
Myc蛋白是哺乳动物细胞增殖的关键调节因子。它们是转录因子，作为与Max蛋白组成的异源二聚体复合物的一部分来激活基因。本综述总结了在理解Myc如何刺激细胞增殖以及这可能如何促进细胞转化和肿瘤发生方面的最新进展。
