Thieffry D, Thomas R
Laboratoire de Génétique des Procaryotes-Université Libre de Bruxelles, Rhode-Saint-Genèse, Belgium.
Pac Symp Biocomput. 1998:77-88.
In this paper, we review the qualitative tools developed by our group for the analysis of regulatory networks. Focusing on the dynamical and biological roles of feedback circuits, this method can be applied in the context of both logical and differential formalisms. This approach already led to several interesting results about the relation between the network structure and the corresponding dynamical properties. In particular, it could be shown that at least one positive regulatory circuit is necessary to generate multistationarity (i.e., alternative states of gene expression), whereas at least one negative circuit is necessary to generate a stable oscillatory behavior. Applications to the analysis of complex gene networks, as well as to the synthesis of regulatory models to account for global expression data are discussed.
在本文中，我们回顾了我们团队开发的用于分析调控网络的定性工具。该方法聚焦于反馈回路的动力学和生物学作用，可应用于逻辑和微分形式体系的背景下。这种方法已经在网络结构与相应动力学特性之间的关系方面取得了一些有趣的成果。特别地，可以证明至少一个正调控回路对于产生多稳态（即基因表达的交替状态）是必要的，而至少一个负回路对于产生稳定的振荡行为是必要的。本文还讨论了该方法在复杂基因网络分析以及用于解释全局表达数据的调控模型合成方面的应用。
