Spona J, Müller-Tyl E, Leodolter S
Z Geburtshilfe Perinatol. 1976 Oct;180(5):356-62.
32 patients with high-risk pregnancies were treated with 3 X 5 mg of 17alpha-ally1-17beta-hydroxy-estr-4-ene (allylestrenol, Gestanon) daily. Only those patients entered this study, who had pathological HPL serum levels during two successive control investigations. In addition, cytological analyses of vaginal smears were performed before treatment was started. The patients were treated with allylestrenol until normal HPL levels were recorded, but at least during 14 days. HPL serum levels were estimated every second day through 14 days. Thereafter HPL assays were performed in weekly intervals. Determinations of HPL were done by radioimmunoassay. Analyses of vaginal smears were done weekly. Statistical analysis of HPL serum levels were performed by Student's-t-test. A statistical significant increase of HPL serum levels were registered during allylestrenol therapy. These results suggest that the pregnancy maintaining effect of allylestrenol is at least partly due to a stimulation of placental function. Analyses of vaginal smears indicate a progestational effect of the norsteroid.
32例高危妊娠患者每天接受3×5毫克的17α-烯丙基-17β-羟基雌甾-4-烯（烯丙雌醇，Gestanon）治疗。只有那些在连续两次对照检查中血清人胎盘催乳素（HPL）水平异常的患者进入本研究。此外，在开始治疗前对阴道涂片进行了细胞学分析。患者接受烯丙雌醇治疗，直至记录到HPL水平正常，但至少持续14天。在14天内每隔一天估计一次HPL血清水平。此后，每周进行一次HPL检测。HPL的测定采用放射免疫分析法。每周对阴道涂片进行分析。HPL血清水平的统计分析采用学生t检验。在烯丙雌醇治疗期间，HPL血清水平有统计学意义的升高。这些结果表明，烯丙雌醇维持妊娠的作用至少部分归因于对胎盘功能的刺激。阴道涂片分析表明该去甲甾体有孕激素样作用。
