细胞因子在嗜酸性粒细胞增多症调节中的作用

Cytokines in the modulation of eosinophilia.

作者信息

Faccioli L H, Vargaftig B B, Medeiros A I, Malheiros A

机构信息

Departamento de Parasitologia, Microbiologia e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 1997;92 Suppl 2:109-14. doi: 10.1590/s0074-02761997000800015.

DOI:10.1590/s0074-02761997000800015

PMID:9698922

Abstract

In this review we discuss our recently results showing interleukin 5 (IL-5) involvement in eosinophil migration and in the maintenance of eosinophilia in blood, bone marrow, lung and peritoneal cavity, in a visceral larva migrans syndrome model using guinea-pigs infected with Toxocara canis. We also describe the sequential release of TNF-alpha and IL-8 during the course of infection. Finally we propose a biological role for IL-5, at least in our model, as a modulator of IL-8 release and secretion.

摘要

在本综述中，我们讨论了我们最近的研究结果，这些结果表明，在使用犬弓首蛔虫感染的豚鼠内脏幼虫移行综合征模型中，白细胞介素5（IL-5）参与嗜酸性粒细胞的迁移以及血液、骨髓、肺和腹腔中嗜酸性粒细胞增多的维持。我们还描述了感染过程中肿瘤坏死因子-α（TNF-α）和白细胞介素-8（IL-8）的相继释放。最后，我们提出IL-5至少在我们的模型中具有作为IL-8释放和分泌调节剂的生物学作用。