Dunstan D W, Puddey I B, Beilin L J, Burke V, Morton A R, Stanton K G
Department of Medicine, University of Western Australia, West Australian Heart Research Institute, Perth, Australia.
Diabetes Res Clin Pract. 1998 Apr;40(1):53-61. doi: 10.1016/s0168-8227(98)00027-8.
This study assessed the effects of short-term circuit weight training (CWT) on glycaemic control in NIDDM. Twenty-seven untrained, sedentary subjects (mean age, 51) with NIDDM participated in an 8-week randomised, controlled study, involving either CWT 3 days/week (n = 15) or no formal exercise (control) (n = 12). All subjects performed regular self-blood glucose monitoring throughout. Fasting serum glucose and insulin were measured following a 12-h fast and during an oral glucose tolerance test (75 g) before and after 8 weeks. Twenty-one subjects completed the study (CWT, n = 11) (Control, n = 10). Strength for all exercises improved significantly after CWT. Pooled time-series analysis, using a random effects model, revealed an overall decrease in self-monitored glucose levels with CWT compared to controls. Significant reductions from baseline values were observed in both the glucose (-213 mmol l-1 per 120 min, P < 0.05) and insulin (-6130 pmol l-1 per 120 min, P < 0.05) area under the curve following CWT relative to controls. After adjustment for body mass changes, the change in self-monitored glucose levels and insulin area under the curve, but not glucose area under the curve, remained significant. Short-term CWT therefore may provide a practical exercise alternative in the lifestyle management of this condition.
本研究评估了短期循环抗阻训练（CWT）对非胰岛素依赖型糖尿病（NIDDM）患者血糖控制的影响。27名未经训练、久坐不动的NIDDM患者（平均年龄51岁）参与了一项为期8周的随机对照研究，其中一组为每周进行3天的CWT训练（n = 15），另一组为不进行正式运动的对照组（n = 12）。所有受试者在整个研究过程中均进行常规的自我血糖监测。在禁食12小时后以及8周前后的口服葡萄糖耐量试验（75克）期间，测量空腹血清葡萄糖和胰岛素水平。21名受试者完成了研究（CWT组，n = 11；对照组，n = 10）。CWT训练后，所有运动项目的力量均有显著提高。采用随机效应模型进行的汇总时间序列分析显示，与对照组相比，CWT组自我监测的血糖水平总体下降。与对照组相比，CWT组在训练后曲线下葡萄糖（每120分钟-2.13 mmol l-1，P < 0.05）和胰岛素（每120分钟-61.30 pmol l-1，P < 0.05）的曲线下面积相对于基线值均有显著降低。在对体重变化进行调整后，自我监测的血糖水平变化和胰岛素曲线下面积变化仍然显著，但葡萄糖曲线下面积变化不再显著。因此，短期CWT训练可能为这种疾病的生活方式管理提供一种实用的运动选择。
