Sundell P M, Roach M R
Department of Medical Biophysics, Health Sciences Centre, University of Western Ontario, London, Canada.
Atherosclerosis. 1998 Jul;139(1):123-9. doi: 10.1016/s0021-9150(98)00068-9.
The role of vessel taper on the distribution of atherosclerotic lesions was examined in 11 photographs of human infra-renal aortas, aged 42-76. The aortas, opened anteriorly and pinned flat with the luminal surface facing up, were analysed using Mocha Imaging software. The circumference was measured at intervals of 10 mm and fitted with a third order polynomial function. Taper was calculated for three segments within each aorta as the angle produced by the slope of the decrease in circumference with length. The percent surface area covered by fatty streaks correlated strongly to the coefficients of the polynomial function, while the raised lesions showed a significant increase with an increase in taper angles in the different segments. The results suggest taper plays a role in the distribution of both fatty streaks and raised lesions, however, the nature of the cause and effect remains to be determined.
在11张年龄在42至76岁的人类肾下腹主动脉照片中，研究了血管锥度对动脉粥样硬化病变分布的作用。这些主动脉从前部打开，管腔面朝上用大头针固定展平，使用Mocha成像软件进行分析。每隔10毫米测量一次周长，并拟合三阶多项式函数。计算每条主动脉内三个节段的锥度，即周长随长度减少的斜率所产生的角度。脂肪条纹覆盖的表面积百分比与多项式函数的系数密切相关，而隆起病变则随着不同节段锥度角的增加而显著增加。结果表明，锥度在脂肪条纹和隆起病变的分布中均起作用，然而，因果关系的本质仍有待确定。
