Hisakawa N, Yasuoka N, Itoh H, Takao T, Jinnouchi C, Nishiya K, Hashimoto K
Second Department of Internal Medicine, Kochi Medical School, Japan.
Endocr J. 1998 Apr;45(2):261-7. doi: 10.1507/endocrj.45.261.
A 45-year-old Japanese woman, treated for Bartter's syndrome for 14 years, presented with complaints of numbness in her extremities and polyarthralgia. She was diagnosed to have Gitelman's syndrome with chondrocalcinosis, which were effectively treated with spironolactone and magnesium supplementation. Gitelman's syndrome is a primary renal tubular disorder characterized by hypomagnesemia and hypocalciuria with normal calcemia. The persistent hypomagnesemia is one of the causes of chondrocalcinosis, and many cases of Bartter's syndrome with hypomagnesemia are associated with chondrocalcinosis attributed to a tubular magnesium defect. We summarize the reported cases with Bartter's syndrome and chondrocalcinosis, referring to the possibility of Gitelman's syndrome.
一名45岁的日本女性，因巴特综合征接受治疗14年，出现肢体麻木和多关节痛的症状。她被诊断为吉特林综合征合并软骨钙质沉着症，通过螺内酯和补充镁进行有效治疗。吉特林综合征是一种原发性肾小管疾病，其特征为低镁血症、低钙尿症且血钙正常。持续性低镁血症是软骨钙质沉着症的病因之一，许多伴有低镁血症的巴特综合征病例与肾小管镁缺乏导致的软骨钙质沉着症有关。我们总结了已报道的巴特综合征合并软骨钙质沉着症的病例，并提及了吉特林综合征的可能性。
