Karlsson K A
Institute of Medical Biochemistry, Göteborg University, Sweden.
Mol Microbiol. 1998 Jul;29(1):1-11. doi: 10.1046/j.1365-2958.1998.00854.x.
The microbe-host interface is currently in focus because of attempts to develop infection therapy in humans based on either natural receptor saccharide (respiratory and gastrointestinal disease) or sophisticated sialic acid analogues designed from crystal structures (influenza). Most of the known host receptors for microbes are glycoconjugates, and the diversity and selectivity of host tissue glycosylation allow for the tropism of infections. However, among the many binding specificities detected so far, the biological role has been proven only in a few infectious model systems. The existence of multiple specificities of a single microbe is both a complicating factor and a challenge, requiring expanded research with a special demand on glycoscience.
由于试图基于天然受体糖类（用于呼吸道和胃肠道疾病）或根据晶体结构设计的复杂唾液酸类似物（用于流感）来开发人类感染治疗方法，微生物 - 宿主界面目前备受关注。大多数已知的微生物宿主受体是糖缀合物，宿主组织糖基化的多样性和选择性决定了感染的嗜性。然而，在迄今为止检测到的众多结合特异性中，只有少数感染模型系统证明了其生物学作用。单一微生物存在多种特异性既是一个复杂因素，也是一项挑战，需要在糖科学方面进行拓展研究并提出特殊要求。
