Karlsson K A
Institute of Medical Biochemistry, Göteborg University, P.O. Box 440, SE-405 30 Göteborg, Sweden.
Adv Exp Med Biol. 2001;491:431-43. doi: 10.1007/978-1-4615-1267-7_28.
Microbe-host protein-carbohydrate interactions are most likely the essential first step to produce an infection, although this has been strictly proven only in a few cases. Improved glycotechnology will help identification of new carbohydrate receptors and this knowledge may be used to identify microbial carbohydrate-binding proteins by affinity proteomics approaches. In some cases such conserved proteins may prove to be successful vaccine components, in other cases, like influenza, saccharide analogues may be the only rational alternative. The prognosis may be, based on these improvements, that infection medicine will make considerable progress in the near future.
微生物与宿主之间的蛋白质 - 碳水化合物相互作用很可能是引发感染的关键第一步，尽管这一点仅在少数情况下得到了严格证实。改进的糖生物学技术将有助于识别新的碳水化合物受体，这些知识可用于通过亲和蛋白质组学方法鉴定微生物碳水化合物结合蛋白。在某些情况下，这类保守蛋白可能被证明是成功的疫苗成分；而在其他情况下，如流感，糖类类似物可能是唯一合理的选择。基于这些进展，未来感染医学有望取得重大进展。
