Sakai Y, Ohga S, Tonegawa Y, Takada H, Nakao F, Nakayama H, Aoki T, Yamamori S, Hara T
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Pediatr Hematol Oncol. 1998 Jul-Aug;20(4):342-6. doi: 10.1097/00043426-199807000-00013.
A patient with aggressive chronic active Epstein-Barr virus (CAEBV) infection is described whose disease activity subsided after interferon (IFN)-alpha therapy.
The patient had intermittent fever, cytopenia, liver dysfunction, hepatosplenomegaly, abnormal titers of EBV-associated antibodies, and positive EBV genomes.
Despite repeated trials of the antiviral agents prednisolone and gamma-globulin, his condition deteriorated. The administration of IFN-alpha (1 x 10(5) U/kg subcutaneously 3 times per week) led to a dramatic clinical improvement. During the IFN-alpha therapy, the rearrangement bands of T-cell antigen receptor genes disappeared assessed by Southern blotting with a decrease in the number of activated T cells, although the EBV-genome remained evident.
These observations suggest that IFN-alpha is useful in managing CAEBV, possibly restraining the clonal development of T-lymphoproliferative disease (LPD) and EBV-associated B-LPD, although it does not eradicate the proliferation of EBV.
描述1例侵袭性慢性活动性EB病毒（CAEBV）感染患者，其疾病活动在干扰素（IFN）-α治疗后消退。
该患者有间歇性发热、血细胞减少、肝功能障碍、肝脾肿大、EBV相关抗体滴度异常以及EBV基因组阳性。
尽管反复试用抗病毒药物泼尼松龙和γ-球蛋白，其病情仍恶化。给予IFN-α（1×10⁵U/kg皮下注射，每周3次）导致临床显著改善。在IFN-α治疗期间，通过Southern印迹法评估，T细胞抗原受体基因的重排条带消失，活化T细胞数量减少，尽管EBV基因组仍然明显。
这些观察结果表明，IFN-α对治疗CAEBV有用，可能抑制T淋巴细胞增殖性疾病（LPD）和EBV相关B-LPD的克隆发展，尽管它不能根除EBV的增殖。
