Nemere I, Farach-Carson M C
Department of Nutrition and Food Sciences, Utah State University, Logan 84322, USA.
Biochem Biophys Res Commun. 1998 Jul 30;248(3):443-9. doi: 10.1006/bbrc.1998.8492.
Steroid hormones, including vitamin D metabolites and estrogens, activate target cells through specific receptors that discriminate among ligands based upon recognition of distinct structural features. For both classes of ligands, cell surface and nuclear receptors co-exist in many target cells. Upon ligand binding, these receptors generate both rapid and long lasting responses. While the structure of the nuclear receptors and their function as transcriptional activators of specific target genes is generally understood, the identity of the membrane receptors remains elusive. Using pharmacological, functional and biochemical approaches, new insights are being gained into nature of the cell surface receptors for both vitamin D metabolites and estrogens.
类固醇激素，包括维生素D代谢产物和雌激素，通过特定受体激活靶细胞，这些受体基于对不同结构特征的识别来区分配体。对于这两类配体，细胞表面受体和核受体在许多靶细胞中同时存在。配体结合后，这些受体产生快速和持久的反应。虽然核受体的结构及其作为特定靶基因转录激活剂的功能已基本清楚，但膜受体的身份仍然难以捉摸。通过药理学、功能和生化方法，人们对维生素D代谢产物和雌激素的细胞表面受体的性质有了新的认识。
