Pietras R J, Nemere I, Szego C M
Department of Medicine/Hematology-Oncology and Jonsson Comprehensive Cancer Center, University of California School of Medicine, Los Angeles 90095-1678, USA.
Endocrine. 2001 Apr;14(3):417-27. doi: 10.1385/ENDO:14:3:417.
Numerous reports of rapid steroid hormone effects in diverse cell types cannot be explained by the generally prevailing theory that centers on the activity of hormone receptors located exclusively in the nucleus. Cell membrane forms of steroid hormone receptors coupled to intracellular signaling pathways may also play an important role in hormone action. Membrane-initiated signals appear to be the primary response of the target cell to steroid hormones and may be prerequisite to subsequent genomic activation. Recent dramatic advances in this area have intensified efforts to delineate the nature and biologic roles of all receptor molecules that function in steroid hormone-signaling pathways. This work has profound implications for our understanding of the physiology and pathophysiology of hormone actions in responsive cells and may lead to development of novel approaches for the treatment of many cell proliferative, metabolic, inflammatory, reproductive, cardiovascular, and neurologic defects.
许多关于类固醇激素在多种细胞类型中产生快速效应的报道，无法用普遍流行的、以仅位于细胞核内的激素受体活性为核心的理论来解释。与细胞内信号通路偶联的类固醇激素受体的细胞膜形式，可能在激素作用中也发挥着重要作用。膜启动信号似乎是靶细胞对类固醇激素的主要反应，并且可能是随后基因组激活的先决条件。该领域最近的重大进展加大了人们对描绘所有在类固醇激素信号通路中起作用的受体分子的性质和生物学作用的努力。这项工作对于我们理解激素在反应性细胞中的生理和病理生理作用具有深远意义，并且可能会带来治疗许多细胞增殖、代谢、炎症、生殖、心血管和神经缺陷的新方法。
