Wagner H N
Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
Semin Nucl Med. 1998 Jul;28(3):213-20. doi: 10.1016/s0001-2998(98)80027-5.
The development of positron emission tomography (PET) illustrates how advances in basic science translates into benefits for human beings. In 1930 Ernest Lawrence and co-workers conceived of the cyclotron. By 1938 Lawrence, Livingston, et al had designed a "medical cyclotron." The subsequent production of C-11, N-13, O-15, and F-18 found many uses in medical and physiologic research. The introduction of F-18 deoxyglucose represents another major step toward practical clinical use of positron-emitting tracers. We have now achieved the transition from the postulation of the existence of positrons to their use in a wide variety of diseases.
正电子发射断层扫描（PET）的发展说明了基础科学的进步是如何转化为对人类的益处的。1930年，欧内斯特·劳伦斯及其同事构思了回旋加速器。到1938年，劳伦斯、利文斯顿等人设计出了“医用回旋加速器”。随后碳-11、氮-13、氧-15和氟-18的生产在医学和生理学研究中有了许多用途。氟-18脱氧葡萄糖的引入代表了正电子发射示踪剂实际临床应用的又一重要进展。我们现在已经实现了从正电子存在的假设到其在多种疾病中的应用的转变。
