皮马印第安人中的类风湿性关节炎：流行病学、人口统计学和系谱学数据的交叉研究
Rheumatoid arthritis in the Pima Indians: the intersection of epidemiologic, demographic, and genealogic data.
作者信息
Hirsch R, Lin J P, Scott W W, Ma L D, Pillemer S R, Kastner D L, Jacobsson L T, Bloch D A, Knowler W C, Bennett P H, Bale S J
机构信息
National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
出版信息
Arthritis Rheum. 1998 Aug;41(8):1464-9. doi: 10.1002/1529-0131(199808)41:8<1464::AID-ART17>3.0.CO;2-X.
OBJECTIVE
To describe the clinical features and familial distribution of rheumatoid arthritis (RA) in the Pima Indians.
METHODS
From 1965 through 1990, all cases of RA as defined by the American College of Rheumatology (formerly, the American Rheumatism Association) 1987 criteria or all cases of seropositive, erosive disease as defined by the Rome criteria were identified in individuals who were age 20 years and older and were of 50% or more Pima/Tohono-O'odham heritage. Radiographs were reviewed by 2 musculoskeletal radiologists who were blinded to case status. Kinship coefficients were used to evaluate familial aggregation.
RESULTS
Eighty-eight RA cases were identified from this population-based sample. Over 66% of the cases had seropositive disease, over 60% had erosive disease, and over 40% had subcutaneous nodules. Of the 88 RA cases, 40 were members of families with more than 1 RA case. The remainder were simplex cases.
CONCLUSION
In this population, clinical markers of severe RA were present in a majority of cases. The presence of familial aggregation for RA in the Pima Indians suggests underlying genetic factors in disease pathogenesis.
目的
描述皮马印第安人中类风湿关节炎（RA）的临床特征和家族分布情况。
方法
在1965年至1990年期间，从年龄在20岁及以上且皮马/托霍诺 - 奥哈姆血统占50%或更多的个体中，识别出所有符合美国风湿病学会（原美国风湿病协会）1987年标准定义的RA病例，或所有符合罗马标准定义的血清阳性、侵蚀性疾病病例。由2名对病例状态不知情的肌肉骨骼放射科医生对X光片进行评估。使用亲属系数来评估家族聚集性。
结果
从这个基于人群的样本中识别出88例RA病例。超过66%的病例患有血清阳性疾病，超过60%患有侵蚀性疾病，超过40%有皮下结节。在这88例RA病例中，40例是来自有不止1例RA病例家庭的成员。其余为单发病例。
结论
在这个人群中，大多数病例存在严重RA的临床标志物。皮马印第安人中RA的家族聚集性表明疾病发病机制中存在潜在的遗传因素。
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