Gildein H P, Kleinert S, Goh T H, Wilkinson J L
Department of Cardiology, Royal Children's Hospital, Melbourne, Australia.
Am Heart J. 1998 Aug;136(2):276-80. doi: 10.1053/hj.1998.v136.89576.
Neonates with critical pulmonary valve stenosis often demonstrate small or hypoplastic right ventricular structures. Relief of the obstruction enhances forward flow across the right ventricle and reduces its pressure load. Growth of the right ventricle and especially of the pulmonary valve annulus was evaluated after balloon dilatation.
Ten consecutive neonates with critical pulmonary valve stenosis who underwent balloon valvuloplasty were studied by serial echocardiography to assess growth of right ventricular structures at follow-up.
The mean diameter of the pulmonary valve annulus increased from 6.1 +/- 1.4 mm to 12.6 +/- 3.5 mm (z scores from -2.9 +/- 1.0 SD to - 1.3 +/- 1.2 SD, p < 0.0001) after a mean follow-up period of 2.7 +/- 2.0 years. The mean diameter of the tricuspid valve annulus increased from 12.9 +/- 3.8 mm to 19.0 +/- 3.1 mm; however, the respective z score did not change significantly (from 0.5 +/- 2.4 SD to -0.5 +/- 1.0 SD). Right ventricular cavity size was hypoplastic in four patients initially and normal in all patients at latest follow-up.
Balloon dilatation of critical pulmonary valve stenosis encourages catch-up growth of the pulmonary valve, and surgery may be avoided even in a hypoplastic pulmonary valve annulus.
患有严重肺动脉瓣狭窄的新生儿通常表现出右心室结构小或发育不全。解除梗阻可增强右心室的前向血流并减轻其压力负荷。在球囊扩张术后评估右心室尤其是肺动脉瓣环的生长情况。
对连续10例接受球囊瓣膜成形术的严重肺动脉瓣狭窄新生儿进行系列超声心动图检查,以评估随访时右心室结构的生长情况。
平均随访2.7±2.0年后,肺动脉瓣环的平均直径从6.1±1.4mm增加到12.6±3.5mm(z值从-2.9±1.0标准差变为-1.3±1.2标准差,p<0.0001)。三尖瓣环的平均直径从12.9±3.8mm增加到19.0±3.1mm;然而,各自的z值没有显著变化(从0.5±2.4标准差变为-0.5±1.0标准差)。最初有4例患者右心室腔大小发育不全,在最近一次随访时所有患者的右心室腔大小均正常。
严重肺动脉瓣狭窄的球囊扩张可促进肺动脉瓣的追赶生长,即使在肺动脉瓣环发育不全的情况下也可避免手术。