Mersch-Sundermann V, Kevekordes S, Jenter C
Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany.
Toxicol Lett. 1998 May;95(3):147-54. doi: 10.1016/s0378-4274(98)00003-4.
Synthetic fragrances are widespread in the environment. Residues were found in animals, human tissues and breast milk. Therefore, six artificial polycyclic musk fragrances--Galaxolide, Tonalide, Celestolide, Phantolide, Cashmeran and Traseolide--were tested for SOS induction using the Escherichia coli PQ37 genotoxicity assay (SOS chromotest) in the presence (+S9) and absence (-S9) of an exogenous metabolizing system. All compounds tested exhibited no SOS inducing potency with the SOS chromotest. These results could be rated as one indicator of the biological inactivity of this group of compounds with respect to genotoxicity.
合成香料在环境中广泛存在。在动物、人体组织和母乳中都发现了其残留。因此，使用大肠杆菌PQ37遗传毒性试验（SOS显色试验），在有（+S9）和无（-S9）外源性代谢系统的情况下，对六种人工多环麝香香料——佳乐麝香、吐纳麝香、celestolide、phantolide、Cashmeran和traseolide进行了SOS诱导测试。所有测试化合物在SOS显色试验中均未表现出SOS诱导能力。这些结果可被视为该组化合物在遗传毒性方面生物无活性的一个指标。
