Cabañes F J, Roura X, García F, Domingo M, Abarca M L, Pastor J
Departament de Patologia i Producció Animals, Hospital Clínic Veterinari, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
J Clin Microbiol. 1998 Sep;36(9):2755-8. doi: 10.1128/JCM.36.9.2755-2758.1998.
A 10-month-old male American Staffordshire terrier was presented to the Autonomous University of Barcelona Veterinary Teaching Hospital because of a 6-month history of a mucopurulent bilateral nasal discharge. The dog had not responded to antibiotics. A follow-up X ray revealed a mixed pattern of osteolysis and increased radiodensity confined to the nasal cavity. Histologic sections of the biopsy specimens revealed the presence of granules containing numerous septate hyphae that were hyaline to pale brown and smooth, one-celled, subspherical-to-elongate conidia that were hyaline to brownish green, and bacteria. Cultures yielded numerous colonies belonging to Scedosporium apiospermum. Susceptibility tests were performed on the isolated strain. The isolate was sensitive to ketoconazole, intermediate to clotrimazole, and resistant to amphotericin B, 5-fluorocytosine, fluconazole, and itraconazole. The dog was treated with oral ketoconazole. During the treatment a general improvement in the lesions was observed. To our knowledge, S. apiospermum has not been implicated previously as an etiologic agent of nasal disease in dogs. This report provides its first description as such.
一只10个月大的雄性美国斯塔福郡梗因双侧黏液脓性鼻分泌物长达6个月的病史，被送至巴塞罗那自治大学兽医教学医院。这只狗对抗生素治疗无反应。后续的X光检查显示鼻腔内有溶骨和放射密度增加的混合模式。活检标本的组织学切片显示存在含有许多分隔菌丝的颗粒，这些菌丝透明至浅棕色且光滑，有透明至棕绿色的单细胞、近球形至细长形分生孢子，还有细菌。培养产生了许多属于尖端赛多孢菌的菌落。对分离菌株进行了药敏试验。该分离株对酮康唑敏感，对克霉唑呈中度敏感，对两性霉素B、5-氟胞嘧啶、氟康唑和伊曲康唑耐药。这只狗接受了口服酮康唑治疗。治疗期间，观察到病变有总体改善。据我们所知，此前尖端赛多孢菌尚未被认为是犬鼻病的病原体。本报告首次对此进行了描述。
