Tsau Y, Guan L, Wu J Y
Institute for Cognitive and Computational Sciences, Georgetown University Medical Center, Washington, DC 20007, USA.
J Neurophysiol. 1998 Aug;80(2):978-82. doi: 10.1152/jn.1998.80.2.978.
Cortical local circuitry is important in epileptogenesis. Voltage-sensitive dyes and fast imaging were used to visualize the initiation of spontaneous paroxysmal events in adult rat neocortical slices. Although spontaneous paroxysmal events could start from anywhere in the preparation, optical imaging revealed that all spontaneous events started at a few confined initiation foci and propagated to the whole preparation. Multielectrode recording over hundreds of spontaneous events revealed that often two or three initiation foci coexisted in each preparation (n = 10). These foci took turns being dominant; the dominant focus initiated the majority of the spontaneous paroxysmal events during that period. The dominant focus and dynamic rearrangement of foci suggest that the initiation of spontaneous epileptiform events involves a local multineuronal process, perhaps with potentiated synapses.
皮质局部回路在癫痫发生过程中起着重要作用。利用电压敏感染料和快速成像技术来观察成年大鼠新皮质切片中自发阵发性事件的起始情况。尽管自发阵发性事件可在标本的任何部位起始，但光学成像显示，所有自发事件均起始于少数几个局限的起始灶，并传播至整个标本。对数百次自发事件进行的多电极记录显示，每个标本中常常同时存在两三个起始灶（n = 10）。这些灶轮流占据主导地位；在该时间段内，主导灶引发了大多数自发阵发性事件。主导灶以及灶的动态重排表明，自发癫痫样事件的起始涉及一个局部多神经元过程，可能与突触增强有关。
