Nutt D J
The Psychopharmacology Unit, University of Bristol, UK.
J Clin Psychiatry. 1998;59 Suppl 8:24-8; discussion 29.
Advances have been made in understanding the biology of panic disorder and the role of the underlying serotonergic dysfunction. This review summarizes the biological evidence for the involvement of serotonin in the pathogenesis of panic disorder and considers the 2 opposing theories that are currently prevalent (5-HT excess and 5-HT deficit). The serotonin selective reuptake inhibitors are increasingly considered as first-line treatment for panic disorder, and the interaction of these agents with the serotonergic system is considered.
在理解惊恐障碍的生物学机制以及潜在的血清素能功能障碍所起的作用方面已经取得了进展。本综述总结了血清素参与惊恐障碍发病机制的生物学证据，并探讨了目前流行的两种相反理论（5-羟色胺过量和5-羟色胺缺乏）。血清素选择性再摄取抑制剂越来越被视为惊恐障碍的一线治疗药物，并对这些药物与血清素能系统的相互作用进行了探讨。
