Newball H H, Menkes H A, Permutt S, Ball W C
Am Rev Respir Dis. 1976 Sep;114(3):639-45. doi: 10.1164/arrd.1976.114.3.639.
A patient with myasthenia gravis, reversible airway obstruction, and a vertical chest wall pressure-volume curve was shown to inflate his lungs to 12 liter during the night. During the day, either spontaneously or after isoproterenol, his functional residual capacity decreased by more than 2 liter. The large lung volume changes occurred without a change in slope of the static pressure-volume curve of the lung above functional residual capacity. The changes in the position of this curve might be due to the the very slow filling and emptying of bullae or to unexplained alterations in the length-tension characteristics of the alveoli. The vertical pressure-volume curve of the chest wall suggested that, unlike other patients who have normal or decreased chest wall compliance, this patient's chest wal was not a factor that limited ventilation at high lung volumes.
一名患有重症肌无力、可逆性气道阻塞且胸壁压力-容积曲线呈垂直状的患者，夜间肺部充气量达12升。白天，无论是自发状态还是在使用异丙肾上腺素后，其功能残气量减少超过2升。在功能残气量以上，肺静态压力-容积曲线斜率无变化的情况下，肺容积出现了大幅变化。该曲线位置的改变可能是由于肺大疱充盈和排空非常缓慢，或者是肺泡长度-张力特性发生了无法解释的改变。胸壁压力-容积曲线呈垂直状表明，与胸壁顺应性正常或降低的其他患者不同，该患者的胸壁在高肺容积时并非限制通气的因素。
