大鼠食管运动前神经元中的生长抑素免疫反应性

Somatostatin immunoreactivity in esophageal premotor neurons of the rat.

作者信息

Broussard D L, Bao X, Altschuler S M

机构信息

Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia, PA 19104, USA.

出版信息

Neurosci Lett. 1998 Jul 10;250(3):201-4. doi: 10.1016/s0304-3940(98)00471-6.

DOI:10.1016/s0304-3940(98)00471-6

PMID:9708867

Abstract

Esophageal peristalsis is coordinated by premotor neurons localized to the central subnucleus of the nucleus of the solitary tract (NTScen). These premotor neurons project directly to motoneurons within the compact formation of the nucleus ambiguus (NAc). Somatostatin immunoreactive terminals have been previously demonstrated encircling motoneurons in the (NAc) (Cunningham, E.T., Jr. and Sawchenko, P.E., J. Neurosci., 9 (1989) 1668-1682). We combined transsynaptic tracing with pseudorabies virus and immunohistochemistry to localize somatostatin to premotor neurons within the NTScen.

摘要

食管蠕动由位于孤束核中央亚核（NTScen）的运动前神经元协调。这些运动前神经元直接投射到疑核致密部（NAc）内的运动神经元。先前已证实生长抑素免疫反应性终末环绕着（NAc）中的运动神经元（坎宁安，E.T.，Jr.和索文科，P.E.，《神经科学杂志》，9（1989）1668 - 1682）。我们将伪狂犬病病毒的跨突触示踪与免疫组织化学相结合，以将生长抑素定位到NTScen内的运动前神经元。