Weiss R A, Whitby D, Talbot S, Kellam P, Boshoff C
Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.
J Natl Cancer Inst Monogr. 1998(23):51-4. doi: 10.1093/oxfordjournals.jncimonographs.a024173.
Kaposi's sarcoma-associated herpesvirus or human herpesvirus type 8 (HHV-8) is present in all forms of Kaposi's sarcoma (KS) as well as in primary effusion lymphomas and some cases of Castleman's disease. In KS tissues, HHV-8 is present in endothelial and spindle cells. Current serologic tests suggest that HHV-8 is predominantly found in those at risk of KS and is not as widespread as most other human herpesviruses. HHV-8 encodes various proteins that may play a role in promotion of cellular growth, including cyclin- and G-coupled protein receptor homologues, and anti-apoptotic proteins, including Bcl-2, IL-6 (i.e., interleukin 6), and FLIP (i.e., FLICE inhibitory protein) homologues. In addition, HHV-8 encodes two macrophage inflammatory-like proteins with anti-human immunodeficiency virus and angiogenic potential.
卡波西肉瘤相关疱疹病毒或人类疱疹病毒8型（HHV-8）存在于所有形式的卡波西肉瘤（KS）以及原发性渗出性淋巴瘤和某些卡斯尔曼病病例中。在KS组织中，HHV-8存在于内皮细胞和梭形细胞中。目前的血清学检测表明，HHV-8主要在有患KS风险的人群中发现，其分布不像大多数其他人类疱疹病毒那样广泛。HHV-8编码多种可能在促进细胞生长中起作用的蛋白质，包括细胞周期蛋白和G偶联蛋白受体同源物，以及抗凋亡蛋白，包括Bcl-2、IL-6（即白细胞介素6）和FLIP（即FLICE抑制蛋白）同源物。此外，HHV-8编码两种具有抗人类免疫缺陷病毒和血管生成潜力的巨噬细胞炎症样蛋白。
