Conn D L, Gleich G J, DeRemee R A, McDonald T J
Ann Rheum Dis. 1976 Aug;35(4):377-80. doi: 10.1136/ard.35.4.377.
Five patients with Wegner's granulomatosis were found to have significantly raised serum immunoglobulin E (IgE) levels. The rise in IgE was not related to the extent of clinical involvement, was not part of a generalized serum immunoglobulin rise, and was not associated with eosinophilia. Raised serum IgE may be a clue to the pathogenesis of this disease.
发现5例韦格纳肉芽肿患者血清免疫球蛋白E（IgE）水平显著升高。IgE升高与临床受累程度无关，不是全身性血清免疫球蛋白升高的一部分，也与嗜酸性粒细胞增多无关。血清IgE升高可能是该疾病发病机制的一个线索。
