Tenling A, Hachenberg T, Tydén H, Wegenius G, Hedenstierna G
Department of Cardiothoracic Anesthesia, University Hospital, Uppsala, Sweden.
Anesthesiology. 1998 Aug;89(2):371-8. doi: 10.1097/00000542-199808000-00013.
Sometimes a high intrapulmonary shunt occurs after cardiac surgery, and impairment of lung function and oxygenation can persist for 1 week after operation. Animal studies have shown that postoperative shunt can be explained by atelectasis. In this study the authors tried to determine if atelectasis can explain shunt in patients who have had cardiac surgery.
Nine patients having coronary artery bypass graft surgery and nine patients having mitral valve surgery were examined using the multiple inert gas elimination technique before and after operation. On the first postoperative day, computed tomography scans were made at three levels of the thorax.
Before anesthesia, the average shunt was low (2+/-3%; range, 0-13%), but on the first postoperative day shunt had increased to 12+/-60% (range, 3-28%). The computed tomography scans showed bilateral dependent densities in all patients but one. The mean area of the densities was 8+/-8% (range, 0-37%) of total lung area, corresponding to a calculated fraction of collapsed lung tissue of 20+/-14% (range, 0-59%). In the basal region, the calculated amount of collapsed tissue was 28+/-19% (range, 0-73%). One mitral valve patient was an outlier and had a large shunt both before and after the operation.
Large atelectasis in the dorsal part of the lungs was found on the first postoperative day after cardiac surgery. However, there was no clear correlation between atelectasis and measured shunt fraction.
心脏手术后有时会出现高肺内分流,肺功能和氧合功能损害可在术后持续1周。动物研究表明,术后分流可用肺不张来解释。在本研究中,作者试图确定肺不张是否能解释心脏手术后患者的分流情况。
对9例行冠状动脉旁路移植术的患者和9例行二尖瓣手术的患者在术前和术后使用多惰性气体消除技术进行检查。术后第1天,在胸部三个层面进行计算机断层扫描。
麻醉前,平均分流较低(2±3%;范围为0 - 13%),但术后第1天分流增加至12±60%(范围为3 - 28%)。计算机断层扫描显示,除1例患者外,所有患者均有双侧肺底部密度增高影。密度增高影的平均面积为全肺面积的8±8%(范围为0 - 37%),对应计算得出的肺萎陷组织比例为20±14%(范围为0 - 59%)。在肺底部区域,计算得出的萎陷组织量为28±19%(范围为0 - 73%)。1例二尖瓣手术患者为异常值,术前和术后均有较大分流。
心脏手术后第1天发现肺背部有大面积肺不张。然而,肺不张与测量的分流分数之间没有明显的相关性。