Bresnihan B, Cunnane G
University College, Dublin, Ireland.
Rheum Dis Clin North Am. 1998 Aug;24(3):615-28. doi: 10.1016/s0889-857x(05)70029-6.
There are three members of the IL-1 gene family: IL-1 alpha, IL-1 beta, and IL-1ra, IL-1 alpha, and IL-1 beta are both antagonist molecules with many proinflammatory effects. IL-1ra is an antagonist molecule that can inhibit the effect of IL-1 alpha and IL-1 beta by specifically blocking the IL-1 receptor on target effector cells. IL-1 alpha and IL-1 beta are considered to be pivotal cytokines in the pathogenesis of many inflammatory diseases. Anti-IL-1 treatment has been shown to cause amelioration of arthritis in animal models and in RA, suggesting that IL-1ra may be an important therapeutic option in the future management of RA.
白细胞介素-1（IL-1）基因家族有三个成员：IL-1α、IL-1β和IL-1受体拮抗剂（IL-1ra）。IL-1α和IL-1β都是具有多种促炎作用的拮抗剂分子。IL-1ra是一种拮抗剂分子，可通过特异性阻断靶效应细胞上的IL-1受体来抑制IL-1α和IL-1β的作用。IL-1α和IL-1β被认为是许多炎症性疾病发病机制中的关键细胞因子。在动物模型和类风湿关节炎（RA）中，抗IL-1治疗已显示可改善关节炎，这表明IL-1ra可能是未来RA治疗的重要选择。
