通过接种LuIII细小病毒诱导新生和胎儿仓鼠感染。
Infection of newborn and fetal hamsters induced by inoculation of LuIII parvovirus.
作者信息
Soike K F, Iatropoulis M, Siegl G
出版信息
Arch Virol. 1976;51(3):235-41. doi: 10.1007/BF01318027.
PMID:971111
Abstract
The LuIII parvovirus was adapted to the newborn hamster and produced a systemic infection with massive intestinal hemorrhage. Inoculation of pregnant hamsters lead to transplacental infection of the fetuses and abortion. Most fetal deaths were observed in animals inoculated on days 8 and 10 of gestation. Virus was recovered from dead fetuses, placentas, and viable fetuses. Histological lesions were found in the heart, liver, kidney and CNS of infected fetuses.
摘要
卢III细小病毒适应新生仓鼠后，会引发全身性感染，并伴有大量肠道出血。给怀孕仓鼠接种该病毒会导致胎儿经胎盘感染并流产。在妊娠第8天和第10天接种病毒的动物中，观察到大多数胎儿死亡。从死亡胎儿、胎盘和存活胎儿中均可分离出病毒。在受感染胎儿的心脏、肝脏、肾脏和中枢神经系统中发现了组织学病变。
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