• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Lymphostin (LK6-A), a novel immunosuppressant from Streptomyces sp. KY11783: taxonomy of the producing organism, fermentation, isolation and biological activities.

作者信息

Nagata H, Ochiai K, Aotani Y, Ando K, Yoshida M, Takahashi I, Tamaoki T

机构信息

Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.

出版信息

J Antibiot (Tokyo). 1997 Jul;50(7):537-42. doi: 10.7164/antibiotics.50.537.

DOI:10.7164/antibiotics.50.537
PMID:9711243
Abstract

In the course of screening for inhibitors of the lymphocyte kinase, Lck (p56lck), aiming at novel immunosuppressants, we isolated a novel alkaloid, lymphostin (LK6-A), from the culture broth of Streptomyces sp. KY11783. Lymphostin was produced in a fermentation medium supplemented with a highly porous polymer resin, which prevented the degradation of this compound in the culture broth. Lymphostin inhibited the kinase activity of Lck with an IC50 value of 0.05 microM, and exhibited potent inhibitory activity against the mixed lymphocyte reaction (MLR) with an IC50 value of 0.009 microM.

摘要

相似文献

1
Lymphostin (LK6-A), a novel immunosuppressant from Streptomyces sp. KY11783: taxonomy of the producing organism, fermentation, isolation and biological activities.
J Antibiot (Tokyo). 1997 Jul;50(7):537-42. doi: 10.7164/antibiotics.50.537.
2
Lymphostin (LK6-A), a novel immunosuppressant from Streptomyces sp. KY11783: structural elucidation.
J Antibiot (Tokyo). 1997 Jul;50(7):543-5. doi: 10.7164/antibiotics.50.543.
3
Inhibition of lymphocyte kinase Lck and phosphatidylinositol 3-kinase by a novel immunosuppressant, lymphostin.新型免疫抑制剂淋巴抑素对淋巴细胞激酶Lck和磷脂酰肌醇3激酶的抑制作用
Biosci Biotechnol Biochem. 2002 Mar;66(3):501-7. doi: 10.1271/bbb.66.501.
4
SNF4435C and D, novel immunosuppressants produced by a strain of Streptomyces spectabilis. I. Taxonomy, fermentation, isolation and biological activities.SNF4435C和D，由壮观链霉菌菌株产生的新型免疫抑制剂。I. 分类学、发酵、分离及生物学活性。
J Antibiot (Tokyo). 2001 Jul;54(7):541-7. doi: 10.7164/antibiotics.54.541.
5
Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. I. Taxonomy of the producing organisms, fermentation and antimicrobial activity.杜纳霉素，一种具有免疫抑制活性的新型螺旋酮24元大环内酯类化合物。I. 产生菌的分类学、发酵及抗菌活性
J Antibiot (Tokyo). 1991 Dec;44(12):1312-7. doi: 10.7164/antibiotics.44.1312.
6
Fluostatins A and B, new inhibitors of dipeptidyl peptidase III, produced by Streptomyces sp. TA-3391. I. Taxonomy of producing strain, production, isolation, physico-chemical properties and biological properties.
J Antibiot (Tokyo). 1998 Jun;51(6):553-9. doi: 10.7164/antibiotics.51.553.
7
SW-163A and B, novel immunosuppressants produced by Streptomyces sp.SW-163A和B，由链霉菌属产生的新型免疫抑制剂。
J Antibiot (Tokyo). 2001 Nov;54(11):867-73. doi: 10.7164/antibiotics.54.867.
8
Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization.环噻霉素，一种具有肾素抑制活性的含聚噻唑新型肽。分类学、发酵、分离及理化特性。
J Antibiot (Tokyo). 1991 Jun;44(6):582-8. doi: 10.7164/antibiotics.44.582.
9
Novel alpha-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp. CK-4416. I. Taxonomy, fermentation and isolation.链霉菌属CK-4416产生的新型α-葡萄糖苷酶抑制剂CKD-711和CKD-711a。I. 分类学、发酵与分离
J Antibiot (Tokyo). 2002 May;55(5):457-61. doi: 10.7164/antibiotics.55.457.
10
Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. I. Taxonomy, fermentation, isolation and biological activity.桑利夫菌素A、B、C和D，从链霉菌属菌株A92 - 308110中分离出的新型亲环素结合化合物。I. 分类学、发酵、分离及生物活性。
J Antibiot (Tokyo). 1999 May;52(5):466-73. doi: 10.7164/antibiotics.52.466.

引用本文的文献

1
Utilization of kinase inhibitors as novel therapeutic drug targets: A review.激酶抑制剂作为新型治疗药物靶点的利用：综述。
Oncol Res. 2023 Feb 3;30(5):221-230. doi: 10.32604/or.2022.027549. eCollection 2022.
2
Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent.以溴二氟乙酸乙酯作为双功能试剂，铜催化8-氨基喹啉酰胺的选择性C5-H溴化和二氟甲基化反应。
RSC Adv. 2023 Mar 1;13(10):6993-6999. doi: 10.1039/d3ra00088e. eCollection 2023 Feb 21.
3
Current Perspectives on Pyrroloiminoquinones: Distribution, Biosynthesis and Drug Discovery Potential.
吡咯并[2,3-f]喹啉醌的研究现状：分布、生物合成及药物研发潜力。
Molecules. 2022 Dec 9;27(24):8724. doi: 10.3390/molecules27248724.
4
Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides.核糖体合成和翻译后修饰肽的作用机制。
Chem Rev. 2022 Sep 28;122(18):14722-14814. doi: 10.1021/acs.chemrev.2c00210. Epub 2022 Sep 1.
5
Substrate Recognition by the Peptidyl-()-2-mercaptoglycine Synthase TglHI during 3-Thiaglutamate Biosynthesis.在 3-硫代谷氨酸生物合成过程中，肽基-（）-2-巯基甘氨酸合成酶 TglHI 的底物识别。
ACS Chem Biol. 2022 Apr 15;17(4):930-940. doi: 10.1021/acschembio.2c00087. Epub 2022 Apr 1.
6
Compounds from Natural Sources as Protein Kinase Inhibitors.天然来源的化合物作为蛋白激酶抑制剂。
Biomolecules. 2020 Nov 12;10(11):1546. doi: 10.3390/biom10111546.
7
Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil.揭示从极端干旱的阿塔卡马沙漠土壤中分离出的新型小单孢菌的潜力。
Sci Rep. 2019 Mar 18;9(1):4678. doi: 10.1038/s41598-019-38789-z.
8
Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.Neolymphostin A 是一种共价磷酸肌醇 3-激酶（PI3K）/哺乳动物雷帕霉素靶蛋白（mTOR）双重抑制剂，采用一种不寻常的亲电乙烯基酯。
J Med Chem. 2018 Dec 13;61(23):10463-10472. doi: 10.1021/acs.jmedchem.8b00975. Epub 2018 Nov 28.
9
Keeping it in the family: Coevolution of latrunculid sponges and their dominant bacterial symbionts.家族内部：扁海绵及其主要细菌共生体的共同进化
Microbiologyopen. 2017 Apr;6(2). doi: 10.1002/mbo3.417. Epub 2016 Oct 26.
10
Use of in situ solid-phase adsorption in microbial natural product fermentation development.原位固相吸附在微生物天然产物发酵开发中的应用。
J Ind Microbiol Biotechnol. 2013 May;40(5):411-25. doi: 10.1007/s10295-013-1247-9. Epub 2013 Mar 23.