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Lymphostin (LK6-A), a novel immunosuppressant from Streptomyces sp. KY11783: structural elucidation.

作者信息

Aotani Y, Nagata H, Yoshida M

机构信息

Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.

出版信息

J Antibiot (Tokyo). 1997 Jul;50(7):543-5. doi: 10.7164/antibiotics.50.543.

DOI:10.7164/antibiotics.50.543
PMID:9711244
Abstract

Lymphostin (LK6-A), a novel immunosuppressant, was isolated from the culture broth of Streptomyces sp. KY11783. Lymphostin showed potent inhibitory activity against the lymphocyte kinase, Lck (p56lck). The structure of lymphostin was determined by spectroscopic methods to be a novel tricyclic aromatic alkaloid. A key feature of the structure is the pyrrolo[4,3,2-de]quinoline moiety which is rare among natural products.

摘要

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