Nagamine Y
Gan. 1978 Jun;69(3):317-22.
Changes of the cell cycle during carcinogenesis of hamster cheek pouch epithelium were studied and it was demonstrated that in hyperplastic and neoplastic stages, the cell cycle time decreased to approximately 2/3 and 1/3 of the normal control, respectively. A nominal growth fraction was found to exceed unity in carcinogen-treated epithelium, whether hyperplastic or neoplastic. This result seems to indicate that a considerable number of cells in which DNA synthesis is stimulated by the carcinogen fail to enter mitosis. A possible implication of repair synthesis is also discussed.
研究了仓鼠颊囊上皮致癌过程中细胞周期的变化，结果表明，在增生和肿瘤形成阶段，细胞周期时间分别降至正常对照的约2/3和1/3。无论是增生性还是肿瘤性的致癌物处理上皮中，名义生长分数均超过1。这一结果似乎表明，相当数量的被致癌物刺激进行DNA合成的细胞未能进入有丝分裂。还讨论了修复合成的可能意义。
