Effects of time zone changes on performance and physiology of airline personnel.

This study is the second of a series of experiments describing the effects of time zone changes on the performance and menstrual cycle changes in a group of 16 female airline personnel. Four groups of four subjects each spent 4 d in the isolation unit of the University of Manchester. One group acted as control; the other three groups were subjected to two 8-h retardations in time, representing Westerly flight. All groups were required to complete an identical battery of workload tasks. In addition, the effects of a therapeutic preparation (mepiprazole hydochloride) were studied in a double-blind experiment. The results of the study confirmed previous experiments in that there was impaired performance in individuals subjected to time zone changes when work was carried out in local time, but the results were difficult to compare with those obtained in Easterly shifts. The therapeutic agent appeared to have little influence on the effect of time zone changes upon subjects, although they reported favourably on its use.