Furuya Y, Takahashi T, Hamamoto H, Nishimura M, Kawakami Y
First Department of Medicine, School of Medicine, Hokkaido University, Sapporo.
Intern Med. 1998 Jul;37(7):642-5. doi: 10.2169/internalmedicine.37.642.
A 46-year-old woman was admitted to our department complaining of dermal eruption and weakness of muscles. She was diagnosed as having dermatomyositis and was initially treated with prednisolone. Since her condition rapidly deteriorated, high-dose intravenous immunoglobulin (i.v.IG) therapy (0.4 g/kg/day i.v. for 5 days) was administered. Marked improvement in muscle strength was observed the following day after the first administration. She unfortunately died of pneumocystis carinii pneumonitis 2 weeks after the i.v.IG therapy. Autopsy revealed no inflammatory cells in the muscles, suggesting that i.v.IG therapy has an important clinical application for refractory dermatomyositis.
一名46岁女性因皮肤疹和肌肉无力入院。她被诊断为皮肌炎，最初接受泼尼松龙治疗。由于病情迅速恶化，给予大剂量静脉注射免疫球蛋白（i.v.IG）治疗（0.4 g/kg/天静脉注射，共5天）。首次给药后第二天观察到肌肉力量有明显改善。不幸的是，她在接受i.v.IG治疗2周后死于卡氏肺孢子虫肺炎。尸检显示肌肉中无炎症细胞，提示i.v.IG治疗对难治性皮肌炎具有重要的临床应用价值。
