Gustafsson A, Lund-Tønnesen S, Berstad A, Midtvedt T, Norin E
Dept. of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Scand J Gastroenterol. 1998 Jul;33(7):721-7. doi: 10.1080/00365529850171666.
Antibiotic-associated diarrhoea (AAD) may range from mild disturbances to severe pseudomembranous colitis. Many antibiotics affect several intestinal microflora-associated characteristics, such as short-chain fatty acid (SCFA) pattern. In the present study we investigated SCFAs in 31 patients on admittance to the hospital for severe AAD. Nine patients were followed up more extensively after they had received an enema containing faecal microflora from a healthy person on a Western diet.
Faecal SCFAs were determined by gas chromatography. The enema was characterized before use.
AAD patients showed significant disturbances in faecal SCFA pattern. Clinically, most enema-treated patients recovered within days and had no relapses within 18 months.
Intestinal microflora showed great disturbances, and the amounts of SCFAs were reduced, although the diarrhoea was not related to total amount SCFAs. Administration of a faecal enema resulted in the clinical recovery of most patients with severe diarrhoea within 4 days.
抗生素相关性腹泻（AAD）的严重程度可从轻度紊乱到严重的伪膜性结肠炎不等。许多抗生素会影响多种与肠道微生物群相关的特征，如短链脂肪酸（SCFA）模式。在本研究中，我们对31例因严重AAD入院的患者的SCFAs进行了调查。9例患者在接受来自食用西方饮食的健康人的含粪便微生物群灌肠后，进行了更广泛的随访。
通过气相色谱法测定粪便SCFAs。在使用前对灌肠剂进行了表征。
AAD患者的粪便SCFA模式存在显著紊乱。临床上，大多数接受灌肠治疗的患者在数天内康复，且在18个月内无复发。
肠道微生物群出现了严重紊乱，SCFAs的量减少，尽管腹泻与SCFAs总量无关。给予粪便灌肠使大多数严重腹泻患者在4天内临床康复。
