LaBonne C, Bronner-Fraser M
Division of Biology, Beckman Institute 139-74, California Institute of Technology, Pasadena 91125, USA.
J Neurobiol. 1998 Aug;36(2):175-89. doi: 10.1002/(sici)1097-4695(199808)36:2<175::aid-neu6>3.0.co;2-z.
The neural crest is a multipotent precursor population which ultimately generates much of the peripheral nervous system, epidermal pigment cells, and a variety of mesectodermal derivatives. Individual multipotent neural crest cells are capable of some self-renewing divisions, and based upon this criteria can be considered stem cells. Considerable progress has been made in recent years toward understanding how this important population of progenitor cells is initially established in the early embryo, and how cell-intrinsic and non-cell-intrinsic factors mediate their subsequent lineage segregation and differentiation.
神经嵴是一种多能前体细胞群体，最终可产生大部分外周神经系统、表皮色素细胞以及多种中胚层衍生物。单个多能神经嵴细胞能够进行一些自我更新分裂，基于这一标准可被视为干细胞。近年来，在理解这一重要的祖细胞群体如何在早期胚胎中最初形成，以及细胞内在和非细胞内在因素如何介导其随后的谱系分离和分化方面取得了相当大的进展。
